No CRISPR, no problem: ‘Jumping gene’ system could be bridge to complex gene editing

A new gene editing technique derived from bacterial “jumping genes” can add, remove, recombine and invert DNA sequences, potentially overcoming some of the limitations of CRISPR. 

The approach is made possible by a molecule called bridge RNA, the discovery of which came about through a joint effort led by scientists at the Arc Institute in Palo Alto, California, in collaboration with the University of Tokyo. They described their work in a pair of papers published June 26 in Nature. 

“We’re excited about the many potential applications that lie ahead,” Patrick Hsu, Ph.D., senior author, told Fierce Biotech in an email. Eventually, the mechanism could be used in cell and gene therapy to, for instance, insert chimeric antigen receptors or missing genes, he said. 

“There are also many functional genomics applications, including possibilities for diseases caused by repeat expansions or genetic translocations which could be addressed by precisely…
Click here to view original post

Click Here to Publish/Feature Your Company or Product News with Biotech Networks