Scientists unveil new way to make large changes to genes, and no CRISPR is required

Scientists led by Patrick Hsu at the Arc Institute in Palo Alto have unveiled a new form of gene editing that can add, remove or flip large stretches of DNA — all without the help of CRISPR.

CRISPR gene editing ushered in a new era for biology just over a decade ago. An easily reprogrammable molecule called a guide RNA, which tells the editing machinery where to cut, is key to its versatility, but CRISPR tools are best at breaking problematic genes or making small edits. Inserting whole genes or making sweeping changes to existing ones is still hard and is increasingly the focus of several new biotech startups.

Hsu’s team has found a way to overcome those challenges in a study published in Nature on…
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