Research Associate I, Protein Engineering in South San Francisco, California

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Xyphos Biosciences , an affiliate of Astellas Pharma Inc. is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products.

We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.

Astellas is announcing a Research Associate I, Protein Engineering opportunity at their Xyphos site in South San Francisco, CA.


The primary focus of the Research Associate I in Protein Engineering will be as a key contributor in support of protein production, purification and analytical characterization / quality control for research purposes. This position will work primarily in a laboratory setting with Scientist and R&D teams.

Essential Job Responsibilities:

  • Supports protein physicochemical analysis / stability studies and demonstrates their predictive value for reagent performance and quality.

  • Supports protein purification and implementation of high throughput / automation for purification using various resin chemistry.

  • Manages protein engineering inventory and database: Standardizes processes, documentation, reagent inventories and captures data to record and share information with Xyphos scientific research team.

  • Cultures and maintains established cell lines, performs DNA transfection for target protein expression and molecular cloning when needed.

  • Performs experiments with careful attention to detail, accurately records procedure / data / results in a timely manner, notes and reports experiments / results that may be out of trend.

  • Collaborates with other members of the R&D team, with other teams within Xyphos.

  • Involved with R&D laboratory management and operation; performs other duties as assigned or special projects as needed.



  • Biotechnology Certification or AA 2-4 or BS degree with 0-3 years of laboratory experience

  • Experience with different protein purification chromatography methods e.g. protein A, Ni-NTA, SEC

  • Experience with analytical / protein stability characterization techniques e.g. SDS-PAGE/CE, aSEC, cIEF/cIEX, HIC and DSF

  • Diligence and meticulous attention to detail in experimentation and record keeping

  • Ability to analyze, interpret data and troubleshooting

  • Self-motivated and willingness to learn and enthusiasm to be part of the development of a cutting-edge therapy platform

  • Adaptability to meet critical production timelines

  • Ability to work independently with supervision and ability to effectively collaborate with other teams; collegiality is a critical attribute

  • Excellent communication and interpersonal skills

  • Strong work ethic with a dedicated mindset of proactively identifying and productively filling gaps


  • Experience in molecular biology and DNA transformation/transfection

  • Experience in SPR (Biacore) /BLI (Octet) kinetic analysis platforms

  • Experience with mammalian cell cultures, expressing and purifying antibodies/secreted proteins


  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program


Category Research and Development

Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans